Human BMP-2 Animal-Free Recombinant Protein

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PC-AF-H-BMP2-100UG
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Bone Morphogenetic Proteins (BMPs) are part of the TGF-β superfamily, a group of structurally related signaling proteins. Among them, BMP-2 stands out as a potent osteoinductive cytokine, capable of prompting bone and cartilage formation when coupled with osteoconductive carriers like collagen and synthetic hydroxyapatite. Besides its role in osteogenesis, BMP-2 contributes significantly to cardiac morphogenesis and is expressed in various tissues such as the lung, spleen, brain, liver, prostate, ovary, and small intestine.

The active form of BMP-2 is a 26 kDa protein made up of two identical 114 amino acid polypeptide chains connected by a single disulfide bond. Each BMP-2 monomer is part of a precursor polypeptide, featuring a 23 amino acid signal sequence for secretion and a 259 amino acid propeptide. Upon precursor dimerization, a furin-type protease cleaves the covalent bonds between the propeptide (also a disulfide-linked homodimer) and the mature BMP-2 ligand.

Recombinant Human/Murine/Rat BMP-2 is a 26.0 kDa homodimeric protein composed of two 115 amino acid polypeptide chains.

 

Product Specifications
 
Species
Human, Mouse, Rat
Published species
Human, Mouse
Expression System E. coli
Amino acid sequence
MQAKHKQRKR LKSSCKRHPL YVDFSDVGWN DWIVAPPGYH AFYCHGECPF PLADHLNSTN HAIVQTLVNS VNSKIPKACC VPTELSAISM LYLDENEKVV LKNYQDMVVE GCGCR
Molecular weight 26 kDa
Class Recombinant
Type Protein
Purity
≥ 98% by SDS-PAGE gel and HPLC analyses.
Endotoxin concentration <0.1 EU/µg
Activity
Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 0.5-1.0 ug/ml.
Conjugate Unconjugated
Form Lyophilized
Purification
HPLC, SDS-PAGE
Contains
no preservative
Storage conditions -20°C

CAUTION

For Research Use Only. Not for use in diagnostic procedures.