Human CNTF Animal-Free Recombinant Protein

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SKU:
PC-AF-H-CNTF-100UG
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CNTF, initially identified as crucial for the survival of chick ciliary neurons in lab cultures, plays a significant role in supporting various neural cell types' survival. These include primary sensory neurons, motor neurons, basal forebrain neurons, and type 2 astrocytes. CNTF's importance extends across different species, showcasing its conserved nature and cross-species effectiveness. The synthetic form, Recombinant Human CNTF, comprises a 199 amino acid polypeptide (22.8 kDa), devoid of a hydrophobic N-terminal signal required for secretion.

Product Specifications  
Species Human 
Published Species Human, Mouse, Rat, Hamster
Expression System E.coli
Amino Acid Sequence  AFTEHSPLTP HRRDLCSRSI WLARKIRSDL TALTQSYVKH QGLNKNINLD SADGMPVAST DQWSQLTQAQ RLQQNLQAYR TFHVLLARLL QDQQVHFTPT QGDFHQAIHT LLLQVAAFAY QIQQLMILLQ YKIPRNQADG MPINVGDGGL FQKKLWGLKV LQQLSQWTVR SIHDLRFISS HQTGIPARGS HYIANNKKM
Molecular Weight  22.8 kDa
Class Recombinant
Type Protein
Purity  ≥ 98% by SDS-PAGE gel and HPLC analyses
Biological Activity Determined by its ability to stimulate proliferation of human TF-1 cells using an ED50 concentration range of 50-150 ng/ml
Endotoxin Levels <0.1 EU/ug
Form Lyophilized
Contains No Preservative
Storage  -20°C
 

CAUTION

For Research Use Only. Not for use in diagnostic procedures.