CNTF, initially identified as crucial for the survival of chick ciliary neurons in lab cultures, plays a significant role in supporting various neural cell types' survival. These include primary sensory neurons, motor neurons, basal forebrain neurons, and type 2 astrocytes. CNTF's importance extends across different species, showcasing its conserved nature and cross-species effectiveness. The synthetic form, Recombinant Human CNTF, comprises a 199 amino acid polypeptide (22.8 kDa), devoid of a hydrophobic N-terminal signal required for secretion.
| Product Specifications | |
| Species | Human |
| Published Species | Human, Mouse, Rat, Hamster |
| Expression System | E.coli |
| Amino Acid Sequence | AFTEHSPLTP HRRDLCSRSI WLARKIRSDL TALTQSYVKH QGLNKNINLD SADGMPVAST DQWSQLTQAQ RLQQNLQAYR TFHVLLARLL QDQQVHFTPT QGDFHQAIHT LLLQVAAFAY QIQQLMILLQ YKIPRNQADG MPINVGDGGL FQKKLWGLKV LQQLSQWTVR SIHDLRFISS HQTGIPARGS HYIANNKKM |
| Molecular Weight | 22.8 kDa |
| Class | Recombinant |
| Type | Protein |
| Purity | ≥ 98% by SDS-PAGE gel and HPLC analyses |
| Biological Activity | Determined by its ability to stimulate proliferation of human TF-1 cells using an ED50 concentration range of 50-150 ng/ml |
| Endotoxin Levels | < 1 EU/ug |
| Form | Lyophilized |
| Contains | No Preservative |
| Storage | -20°C |
CAUTION
For Research Use Only. Not for use in diagnostic procedures.
