Human GM-CSF Recombinant Protein

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SKU:
PC-H-GMCSF-100UG
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GM-CSF, a hematopoietic growth factor, plays a role in stimulating the development of neutrophils and macrophages while also supporting the proliferation and maturation of early erythroid, megakaryocytic, and eosinophilic progenitor cells. It's primarily produced in endothelial cells, monocytes, fibroblasts, and T-lymphocytes. GM-CSF has the additional effect of inhibiting neutrophil migration and boosting the functional activity of mature end cells. Unlike G-CSF, GM-CSF molecules are species-specific with no cross-reactivity between Human and murine versions. Recombinant Human GM-CSF is a 14.6 kDa globular protein comprising 128 amino acids, featuring two intramolecular disulfide bonds and two potential N-linked glycosylation sites.

 

Product Specifications
 
Species Human
Published species
Human, Mouse
Expression System E. coli
Amino acid sequence
MAPARSPSPS TQPWEHVNAI QEARRLLNLS RDTAAEMNET VEVISEMFDL QEPTCLQTRL ELYKQGLRGS LTKLKGPLTM MASHYKQHCP PTPETSCATQ IITFESFKEN LKDFLLVIPF DCWEPVQE
Molecular weight 14.6 kDa
Class Recombinant
Type Protein
Purity
≥ 98% by SDS-PAGE gel and HPLC analyses.
Endotoxin concentration <1 EU/µg
Activity
The ED50 was determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is ≤ 0.1 ng/ml, corresponding to a specific activity of ≥ 1 x 10^7 units/mg.
Conjugate Unconjugated
Form Lyophilized
Contains
no preservative
Storage conditions -20°C

CAUTION

For Research Use Only. Not for use in diagnostic procedures