Human IL-1 alpha Animal-Free Recombinant Protein

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SKU:
PC-AF-H-IL1-A-100UG
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IL-1α is a proinflammatory cytokine that is not secreted; it is produced by various cells like monocytes, tissue macrophages, keratinocytes, and other epithelial cells. Both IL-1α and IL-1β bind to the same receptor and share similar, if not identical, biological properties. These cytokines have diverse effects, including stimulating thymocyte proliferation by triggering IL-2 release, fostering B-cell maturation and proliferation, exhibiting mitogenic FGF-like activity, and prompting the release of prostaglandin and collagenase from synovial cells.

However, there is a notable difference: IL-1β is secreted, while IL-1α primarily remains associated with cells. The recombinant Human IL-1α is an 18.0 kDa protein comprising 159 amino acid residues.

 

Product Specifications
 
Species Human
Published species
Human, Mouse
Expression System E. coli
Amino acid sequence
SAPFSFLSNV KYNFMRIIKY EFILNDALNQ SIIRANDQYL TAAALHNLDE AVKFDMGAYK SSKDDAKITV ILRISKTQLY VTAQDEDQPV LLKEMPEIPK TITGSETNLL FFWETHGTKN YFTSVAHPNL FIATKQDYWV CLAGGPPSIT DFQILENQA
Molecular weight 18 kDa
Class Recombinant
Type Protein
Purity
≥ 98% by SDS-PAGE gel and HPLC analyses.
Endotoxin concentration <0.1 EU/µg
Activity
Determined by its ability to stimulate the proliferation of mouse D10S cells. The expected ED50 is ≤0.001 ng/ml, corresponding to a specific activity of ≥1 x 10^9 units/mg.
Conjugate Unconjugated
Form Lyophilized
Contains
no preservative
Storage conditions -20°C

CAUTION

For Research Use Only. Not for use in diagnostic procedures.