IL-11, a versatile cytokine, is synthesized by stromal cells like fibroblasts, epithelial cells, and osteoclasts. Its expression spans various tissues such as the thymus, lung, bone, connective tissue, and central nervous system. IL-11 holds a crucial regulatory role in hematopoiesis by stimulating the growth of myeloid, erythroid, and megakaryocyte progenitor cells. Additionally, it influences bone metabolism, suppresses the production of proinflammatory cytokines, and provides protection against gastromucosal injury.
Recombinant Human IL-11 is a 19.3 kDa protein comprising 179 amino acid residues.
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Product Specifications
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| Species | Human |
| Published species |
Human, Mouse
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| Expression System | E. coli |
| Amino acid sequence |
MPGPPPGPPR VSPDPRAELD STVLLTRSLL ADTRQLAAQL RDKFPADGDH NLDSLPTLAM SAGALGALQL PGVLTRLRAD LLSYLRHVQW LRRAGGSSLK TLEPELGTLQ ARLDRLLRRL QLLMSRLALP QPPPDPPAPP LAPPSSAWGG IRAAHAILGG LHLTLDWAVR GLLLLKTRL
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| Molecular weight | 19.3 kDa |
| Class | Recombinant |
| Type | Protein |
| Purity |
≥ 98% by SDS-PAGE gel and HPLC analyses.
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| Endotoxin concentration | <0.1 EU/µg |
| Activity |
The ED50 was determined by the dose-dependent stimulation of the proliferation of murine T11 cells is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 10^5 units/mg.
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| Conjugate | Unconjugated |
| Form | Lyophilized |
| Contains |
no preservative
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| Storage conditions | -20°C |
CAUTION
For Research Use Only. Not for use in diagnostic procedures.
