IL-15 serves as an immunomodulatory cytokine that triggers the growth of T lymphocytes, sharing numerous traits with IL-2. Its primary effects are directed towards T cells, aiding in their development, longevity, and activation. Moreover, IL-15 plays a crucial role in nurturing and activating natural killer (NK) cells. Elevated IL-15 levels have been associated with conditions such as rheumatoid arthritis, inflammatory bowel disease, and diseases linked to retroviruses like HIV and HTLV-I.
In experiments, Human IL-15 has demonstrated biological activity on mouse cells, notably by stimulating the dose-dependent proliferation of mouse CTLL cells. This recombinant protein, consisting of 115 amino acid residues and weighing 12.9 kDa, mirrors these functions.
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Product Specifications
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| Species | Human |
| Published species |
Hamster, Human, Mouse
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| Expression System | E. coli |
| Amino acid sequence |
MNWVNVISDL KKIEDLIQSM HIDATLYTES DVHPSCKVTA MKCFLLELQV ISLESGDASI HDTVENLIIL ANNSLSSNGN VTESGCKECE ELEEKNIKEF LQSFVHIVQM FINTS
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| Molecular weight | 12.9 kDa |
| Class | Recombinant |
| Type | Protein |
| Purity |
≥ 98% by SDS-PAGE gel and HPLC analyses.
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| Endotoxin concentration | <1 EU/µg |
| Activity |
Determined by its ability to stimulate the proliferation of mouse CTLL-2 cells. The expected ED50 is ≤ 0.5 ng/ml, corresponding to a specific activity of ≥ 2 x 10^6 units/mg.
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| Conjugate | Unconjugated |
| Form | Lyophilized |
| Contains |
no preservative
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| Storage conditions | -20°C |
CAUTION
For Research Use Only. Not for use in diagnostic procedures.
