Originally identified as IL-17 and now referred to as IL-17A, this protein is a homodimer consisting of two 136 amino acid chains. It is released by activated T-cells and acts on stromal cells, triggering the production of proinflammatory and hematopoietic bioactive molecules. Today, IL-17 encompasses a family of structurally-related cytokines with a highly conserved C-terminal region. However, they vary in their N-terminal regions and exhibit distinct biological functions. The family includes six members known as IL-17A through IL-17F, all of which are secreted as homodimers.
Of note, IL-17A demonstrates bioactivity across species, showing effectiveness in both Human and murine cells. The recombinant Human IL-17A is a 31.3 kDa disulfide-linked homodimer composed of two 137 amino acid polypeptide chains.
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Product Specifications
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| Species | Human |
| Published species |
Bovine, Human, Mouse
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| Expression System | E. coli |
| Amino acid sequence |
MIVKAGITIP RNPGCPNSED KNFPRTVMVN LNIHNRNTNT NPKRSSDYYN RSTSPWNLHR NEDPERYPSV IWEAKCRHLG CINADGNVDY HMNSVPIQQE ILVLRREPPH CPNSFRLEKI LVSVGCTCVT PIVHHVA
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| Molecular weight | 31.3 kDa |
| Class | Recombinant |
| Type | Protein |
| Purity |
≥ 98% by SDS-PAGE gel and HPLC analyses.
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| Endotoxin concentration | <0.1 EU/µg |
| Activity |
Measured by its ability to induce IL-6 production by NHDF cells using a concentration range of 0.5-1.5 ng/ml.
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| Conjugate | Unconjugated |
| Form | Lyophilized |
| Contains |
no preservative
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| Storage conditions | -20°C |
CAUTION
For Research Use Only. Not for use in diagnostic procedures.
