The Human IL-18 Recombinant protein is a premium-grade product derived from the gene responsible for encoding a potent proinflammatory cytokine. This cytokine has the capacity to stimulate IFN-gamma production in T cells, crucial for the immune response. Furthermore, in conjunction with IL12, it has been observed to inhibit the generation of IL4-dependent IgE and IgG1 by B cells while simultaneously boosting IgG2a production, an essential immunoglobulin.
To ensure optimal functionality, our Human IL-18 Recombinant protein is combined with IL-18 binding protein. This component can selectively interact with the cytokine, modulating its biological activity as needed.
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Product Specifications
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| Species | Human |
| Expression System | E. coli |
| Amino acid sequence | YFGKLESKLSVIRNLNDQVLFIDQGNRPLFEDMTDSDCRDNAPRTIFIIS MYKDSQPRGMAVTISVKCEKISTLSCENKIISFKEMNPPDNIKDTKSDII FFQRSVPGHDNKMQFESSSYEGYFLACEKERDLFKLILKKEDELGDRSIM FTVQNED |
| Molecular weight | 18 kDa |
| Class | Recombinant |
| Type | Protein |
| Purity | >95% by SDS-PAGE |
| Endotoxin concentration | <1 EU/µg |
| Activity |
Determined by the dose-dependent production of IFN-gamma by human KG-1 myelomonocyte cells.
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| Conjugate | Unconjugated |
| Form | Lyophilized |
| Contains | no preservative |
| Storage Conditions | -20°C |
CAUTION
For Research Use Only. Not for use in diagnostic procedures.
