IL-2 stands out as a potent immunoregulatory lymphokine generated by T cells following antigenic or mitogenic stimulation. Its signaling through IL-2R is critical for T cell proliferation and other vital immune response activities. IL-2 plays a pivotal role in stimulating the growth and differentiation of various immune cells like B cells, NK cells, lymphokine-activated killer cells, monocytes, macrophages, and oligodendrocytes.
The recombinant Human IL-2 is a 15.5 kDa protein composed of 134 amino acid residues, featuring one intrachain disulfide bond.
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Product Specifications
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| Species | Human |
| Published species |
Bovine, Human, Mouse
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| Expression System | E. coli |
| Amino acid sequence |
MAPTSSSTKK TQLQLEHLLL DLQMILNGIN NYKNPKLTRM LTFKFYMPKK ATELKHLQCL EEELKPLEEV LNLAQSKNFH LRPRDLISNI NVIVLELKGS ETTFMCEYAD ETATIVEFLN RWITFAQSII STLT
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| Molecular weight | 15.5 kDa |
| Class | Recombinant |
| Type | Protein |
| Purity |
≥ 98% by SDS-PAGE gel and HPLC analyses.
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| Endotoxin concentration | <0.1 EU/µg |
| Activity |
The ED50 was determined by the dose-dependent stimulation of the proliferation of murine CTLL-2 cells is ≤ 0.1 ng/ml, corresponding to a specific activity of ≥ 1 x 10^7 units/mg.
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| Conjugate | Unconjugated |
| Form | Lyophilized |
| Contains |
no preservative
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| Storage conditions | -20°C |
CAUTION
For Research Use Only. Not for use in diagnostic procedures.
