IL-5 functions as a growth factor in hematopoiesis, fostering the proliferation and activation of eosinophils. Its production primarily stems from mast cells, T cells, and eosinophils themselves. IL-5 plays a pivotal role in bolstering cell-mediated immunity against parasitic infections and specific tumors. Elevated IL-5 levels correlate with eosinophilia, a condition associated with the onset of asthma and other allergic disorders. Notably, both human and murine IL-5 exhibit cross-species reactivity. Recombinant Human IL-5 constitutes a 26.5 kDa disulfide-linked homodimeric protein, comprised of two 116 amino acid chains.
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Product Specifications
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| Species | Human |
| Published Species | Human, Monkey, Mouse |
| Expression System | E. coli |
| Amino acid sequence |
MIPTEIPTSA LVKETLALLS THRTLLIANE TLRIPVPVHK NHQLCTEEIF QGIGTLESQT VQGGTVERLF KNLSLIKKYI DGQKKKCGEE RRRVNQFLDY LQEFLGVMNT EWIIES
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| Molecular weight | 26.5 kDa |
| Class | Recombinant |
| Type | Protein |
| Purity |
≥ 98% by SDS-PAGE gel and HPLC analyses.
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| Endotoxin concentration | <0.1 EU/µg |
| Activity |
The ED50 as determined by the dose-dependent proliferation of TF-1 cells was ≤ 0.15 ng/ml, corresponding to a specific activity of ≥ 6.6 x 10^6 units/mg.
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| Conjugate | Unconjugated |
| Form | Lyophilized |
| Contains |
no preservative
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| Storage conditions | -20°C |
CAUTION
For Research Use Only. Not for use in diagnostic procedures.
