KGF (FGF-7), also known as Keratinocyte Growth Factor, is a member of the FGF family, which comprises 23 known proteins. This family of proteins holds a critical position in prenatal development, postnatal growth, and the regeneration of various tissues, achieving this through the promotion of cellular proliferation and differentiation. Specifically, KGF (FGF-7) acts as a mitogenic factor targeting epithelial cells and keratinocytes.
KGF (FGF-7) transmits its signals via FGFR 2b and contributes significantly to kidney and lung development, as well as angiogenesis and wound healing processes. The recombinant Human KGF (FGF-7) is an 18.9 kDa protein composed of 163 amino acid residues.
| Product Specifications | |
| Species | Human |
| Published Species | Human, Mouse, Rat |
| Expression System | E.Coli |
| Amino Acid Sequence | CNDMTPEQMA TNVNCSSPER HTRSYDYMEG GDIRVRRLFC RTQWYLRIDK RGKVKGTQEM KNNYNIMEIR TVAVGIVAIK GVESEFYLAM NKEGKLYAKK ECNEDCNFKE LILENHYNTY ASAKWTHNGG EMFVALNQKG IPVRGKKTKK EQKTAHFLPM AIT |
| Molecular Weight | 18.9 kDa |
| Class | Recombinant |
| Type | Protein |
| Purity | ≥ 98% by SDS-PAGE gel and HPLC analyses |
| Endotoxin concentration | <0.1 EU/µg |
| Activity | Determined by a cell proliferation assay using 4MBr-5 cells. The expected ED50 for this effect is 0.1-15 ng/ml. |
| Form | Lyophilized |
| Contains | No Preservative |
CAUTION
For Research Use Only. Not for use in diagnostic procedures.
