NT-3, a neurotrophic factor, shares structural kinship with β-NGF, BDNF, and NT-4, all part of the cysteine-knot family of growth factors known for their stable dimeric structures. It's predominantly expressed by neurons in the central nervous system and activates signaling pathways through the trk receptors. NT-3 plays a vital role in promoting the growth and survival of both nerve cells and glial cells. Notably, the amino acid sequences of Human, murine, and rat NT-3 are identical. Recombinant Human NT-3 forms a noncovalently linked homodimer consisting of two 13.6 kDa polypeptide monomers, totaling 240 amino acid residues.
Product Specifications
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|
Species | Human |
Published species |
Human, Mouse, Rat
|
Expression System | E. coli |
Amino acid sequence |
MYAEHKSHRG EYSVCDSESL WVTDKSSAID IRGHQVTVLG EIKTGNSPVK QYFYETRCKE ARPVKNGCRG IDDKHWNSQC KTSQTYVRAL TSENNKLVGW RWIRIDTSCV CALSRKIGRT
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Molecular weight | 27.2 kDa |
Class | Recombinant |
Type | Protein |
Purity |
≥ 98% by SDS-PAGE gel and HPLC analyses.
|
Endotoxin concentration | <0.1 EU/µg |
Activity |
Determined by its ability to bind recombinant human TrkB Fc Chimera in a functional ELISA.
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Conjugate | Unconjugated |
Form | Lyophilized |
Contains |
no preservative
|
Storage conditions | -20°C |
CAUTION
For Research Use Only. Not for use in diagnostic procedures.