NT-4 is a neurotrophic factor sharing structural similarities with β-NGF, BDNF, and NT-3, all part of the cysteine-knot family of growth factors characterized by stable dimeric structures. It is expressed in various tissues such as the prostate, thymus, placenta, and skeletal muscle. NT-4 can activate signaling pathways through the LNGFR and trkB receptors, leading to the survival of peripheral sensory sympathetic neurons. Recombinant Human NT-4 exists as a noncovalently linked homodimer comprising two 14.0 kDa polypeptide monomers, totaling 260 amino acid residues.
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Product Specifications
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| Species | Human |
| Published species | Human |
| Expression System | E. coli |
| Amino acid sequence |
GVSETAPASR RGELAVCDAV SGWVTDRRTA VDLRGREVEV LGEVPAAGGS PLRQYFFETR CKADNAEEGG PGAGGGGCRG VDRRHWVSEC KAKQSYVRAL TADAQGRVGW RWIRIDTACV CTLLSRTGRA
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| Molecular weight | 28.1 kDa |
| Class | Recombinant |
| Type | Protein |
| Purity |
≥ 98% by SDS-PAGE gel and HPLC analyses.
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| Endotoxin concentration | <0.1 EU/µg |
| Activity |
Determined by its ability to bind recombinant human TrkB Fc Chimera in a functional ELISA.
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| Conjugate | Unconjugated |
| Form | Lyophilized |
| Contains |
no preservative
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| Storage conditions | -20°C |
CAUTION
For Research Use Only. Not for use in diagnostic procedures.
