Recombinant Murine Noggin is a high-purity, animal-free recombinant protein expressed to mimic the biological activity of native mouse Noggin, a secreted antagonist of bone morphogenetic proteins (BMPs). Noggin plays a critical role in embryonic development and tissue patterning by binding BMPs and preventing receptor interaction, making it an essential tool for stem cell research, developmental biology, and regenerative medicine studies.
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Product Specifications |
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Species |
Mouse |
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Published species |
Mouse |
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Expression System |
E. coli |
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Amino acid sequence |
MQHYLHIRPA PSDNLPLVDL IEHPDPIFDP KEKDLNETLL RSLLGGHYDP GFMATSPPED RPGGGGGPAG GAEDLAELDQ LLRQRPSGAM PSEIKGLEFS EGLAQGKKQR LSKKLRRKLQ MWLWSQTFCP VLYAWNDLGS RFWPRYVKVG SCFSKRSCSV PEGMVCKPSK SVHLTVLRWR CQRRGGQRCG WIPIQYPIIS ECKCSC |
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Molecular weight |
46.4 kDa |
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Class |
Recombinant |
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Type |
Protein |
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Purity |
≥ 98% by SDS-PAGE gel and HPLC analyses. |
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Endotoxin concentration |
<0.1 EU/µg |
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Activity |
Determined by its ability to inhibit 5.0 ng/ml of BMP-4 induced alkaline phosphatase production by ATDC5 chondrogenic cells. The expected ED50 for this effect is 1.0-2.0 ng/ml of Noggin. |
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Conjugate |
Unconjugated |
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Form |
Lyophilized |
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Contains |
no preservative |
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Storage conditions |
-20°C |
CAUTION
For Research Use Only. Not for use in diagnostic procedures.
